Cerulenin
Catalogue Number: C4653-APE
| Manufacturer: | Apexbio |
| Molecular Formula: | C12H17NO3 |
| Physical state: | A crystalline solid |
| Type: | Enzyme Inhibitors |
| Shipping Condition: | Blue Ice |
| Unit(s): | 10 mg, 5 mg, 50 mg |
Description
Description: Cerulenin is a widely used natural inhibitor of fatty acid synthase (FAS). In primary rat aortic endothelial cells, the inhibitor of fatty acid synthase and HMG-CoA reductase, Cerulenin (5 µg/mL) and Lovastatin, are used before palmitic acid added. The mRNA expression of IL-1β, TNFα, VCAM-1 and IL-6 are reduced while NO production is recovered with inhibitor treatment[2]. In ob/ob mice, cerulenin effectively depletes fat content in the steatotic liver, which trigger a series of reactions: Decreased expression of PPARα and γ reduced UCP2 levels, increase liver ATP content, and reduce ROS production. Elevated intracellular ATP levels and reduced ROS ultimately improved liver function. References:[1]. Bitencourt T A, et al. Trans-chalcone and quercetin down-regulate fatty acid synthase gene expression and reduce ergosterol content in the human pathogenic dermatophyte Trichophyton rubrum. BMC Complement Altern Med, 2013, 13(1): 229.[2]. Tian D, et al. Overexpression of steroidogenic acute regulatory protein in rat aortic endothelial cells attenuates palmitic acid-induced inflammation and reduction in nitric oxide bioavailability. Cardiovasc Diabetol, 2012, 11(1): 144.[3]. Cheng G, et al. Cerulenin blockade of fatty acid synthase reverses hepatic steatosis in ob/ob mice. PLoS One, 2013, 8(9): e75980.
Additional Text
Storage Note
Store at -20°C
Solubility
≤20mg/ml in ethanol;25mg/ml in DMSO;30mg/ml in dimethyl formamide
Smile String
C/C=C/C/C=C/CCC([C@@H]1[C@H](C(N)=O)O1)=O
C4653 CofA
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