5'-deoxy Thymidine

Catalogue Number: C4692-APE

Manufacturer:	Apexbio
Molecular Formula:	C10H14N2O4
Physical state:	A crystalline solid
Type:	Antibiotics and Antimycotics
Shipping Condition:	Blue Ice
Unit(s):	10 mg, 5 mg

Overview
Datasheets

Description

Description: 5'-Deoxy Thymidine has been used as a research tool for antiviral and anticancer studies. 5'-Deoxy Thymidine can be used to study the entry mechanism into human erythrocytes in comparison with other deoxythymidines. Deoxythymidine, also named as thymidine, is the DNA nucleoside T. Deoxythymidine can pair with deoxyadenosine (A) in double-stranded DNA. 5'-deoxy Thymidine is a form of thymidine which had the hydroxyl group at the 5' position replaced with hydrogen [1]. 5'-deoxy Thymidine (50 µg/mL) was effective against Bacillus subtilis and Staphylococcus aureus [1]. The MBC of 5'-deoxy Thymidine was 50 µg/mL. 5'-deoxy Thymidine has been used as an antibacterial agent in medical situations [1].Thymidine has been phosphorylated at the hydroxyl group on carbon 5 of the ribose moiety before polymerization into DNA. 5'-Deoxy Thymidine cannot be phosphorylated and used by DNA polymerase in the synthesis of DNA. In human erythrocytes, 5'-Deoxy Thymidine was readily and nonconcentratively uptaked by metabolism, and could be partially inhibited by nucleosides or inhibitors of nucleoside transport at micromolar concentrations [2].References:[1] Hatano A, Nishimura M, Souta I. Impact of unnatural nucleosides on the control of microbial growth[J]. Biocontrol science, 2009, 14(2): 55-60. [2] Domin B A, Mahony W B, Koszalka G W, et al. Membrane permeation characteristics of 5'-modified thymidine analogs[J]. Molecular pharmacology, 1992, 41(5): 950-956.

Additional Text

Storage Note

Store at -20°C

Molecular Formula

C10H14N2O4

Molecular Weight

226.2

CAS Number

3458-14-8

Smile String

CC1=CN(C(NC1=O)=O)[C@H]2C[C@H](O)[C@@H](C)O2

C4692 CofA

C4692 MSDS

Price

£417.00

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