Indomethacin heptyl ester
Catalogue Number: C4718-APE
| Manufacturer: | Apexbio |
| Molecular Formula: | C26H30ClNO4 |
| Physical state: | A solution in acetate. To change the solvent, simply evaporate the acetate containing under a gentle stream of nitrogen and immediately add the solvent of choice. |
| Type: | Other Inhibitors |
| Shipping Condition: | Blue Ice |
| Unit(s): | 10 mg, 5 mg, 50 mg |
Description
Description: Indomethacin heptyl ester is a potent and selective COX-2 inhibitor with IC50 value of 0.04 µM [1]. The key step in thromboxane and prostaglandin biosynthesis involves the conversion of arachidonic acid to prostaglandin H2 (PGH2), a reaction catalyzed by the cyclooxygenase (COX) and peroxidase activities of prostaglandin endoperoxide synthase or cyclooxygenase. COX is composed of COX-1 and COX-2. COX-2 plays important role in prostaglandin biosynthesis in inflammatory cells and in the central nervous system [1]. Indomethacin is a potent COX-1 and COX-2 inhibitor with IC50 value of 0.05 µM and 0.75 µM, and is also a nonsteroidal antiinflammatory drug. Indomethacin is a substituted indole acetic acid and many of the structurally diverse indomethacin esters and amides show enhanced selectivity for the COX-2 isoform. Indomethacin heptyl ester was more potent and selective COX-2 inhibitor with IC50 value of 0.04 µM and >66 µM for human recombinant COX-2 and COX-1, respectively [1]. Reference:[1]. Kalgutkar AS, Marnett AB, Crews BC, et al. Ester and amide derivatives of the nonsteroidal antiinflammatory drug, indomethacin, as selective cyclooxygenase-2 inhibitors. J Med Chem. 2000 Jul 27;43(15):2860-70.
Additional Text
Storage Note
Store at -20°C
Solubility
≤17mg/ml in ethanol;17mg/ml in DMSO;17mg/ml in dimethyl formamide
Smile String
ClC1=CC=C(C(N2C(C=CC(OC)=C3)=C3C(CC(OCCCCCCC)=O)=C2C)=O)C=C1
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