MLS-573151
Catalogue Number: C4738-APE
| Manufacturer: | Apexbio |
| Molecular Formula: | C21H19N3O2S |
| Physical state: | A crystalline solid |
| Type: | Other Inhibitors |
| Shipping Condition: | Blue Ice |
| Unit(s): | 10 mg, 25 mg, 5 mg |
Description
Description: MLS-573151 is a specific and cell permeable inhibitor of Cdc42 [1]. Cdc42 is a small GTPase of the Rho family involved in regulating signaling pathways that control diverse cellular functions such as cell morphology, cell migration, cell cycle progression and endocytosis [2]. In vitro: MLS-573151 was a specific, cell permeable inhibitor of Cdc42 with an IC50 of 2 µM [1]. MLS-573151 showed no effect on other GTPases, including the related Rho family members RhoA, Rac1, and Rac2. MLS-573151 functioned by blocking the binding of GTP to Cdc42 [1]. In marrow-derived mesenchymal stem cells, MLS-573151 showed no effect on cell migration [3]. References:[1] Surviladze Z, Waller A, Wu Y, et al. Identification of a small GTPase inhibitor using a high-throughput flow cytometry bead-based multiplex assay[J]. Journal of biomolecular screening, 2010, 15(1): 10-20.[2] Qadir M I, Parveen A, Ali M. Cdc42: Role in Cancer Management[J]. Chemical biology & drug design, 2015, 86(4): 432-439.[3] Wang L, Yang L, Tian L, et al. Cannabinoid Receptor 1 Mediates Homing of Bone Marrow-Derived Mesenchymal Stem Cells Triggered by Chronic Liver Injury[J]. Journal of cellular physiology, 2017, 232(1): 110-121.
Additional Text
Storage Note
Store at -20°C
Smile String
NS(C(C=C1)=CC=C1N2C(C3=CC=CC=C3)CC(C4=CC=CC=C4)=N2)(=O)=O
Solubility
≥42.9 mg/mL in DMSO; insoluble in EtOH; insoluble in H2O
C4738 CofA
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