Chondroitin Sulfate Proteoglycan (NG2, CSPG) (APC)
Catalogue Number: C5067-71F-APC-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with Allophycocyanin (APC). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 6A38 |
| Isotype: | IgG1, kappa |
| Immunogen: | Purified rat Chondroitin Sulfate Proteoglycan. |
| Application: | IF, IP, WB, IHC, FLISA |
Description
Description: The NG2 chondroitin sulfate proteoglycan is a valuable marker for many types of immature progenitor cells including pericytes/smooth muscle cells, chondroblasts and oligodendrocyte progenitors. NG2 is often expressed in melanomas, chondrosarcomas, glioblastomas and myeloid leukemias. Studies indicate that NG2 is involved in modulating cellular response to growth factors and cell motility; these are critical functions in proliferation and migration of immature progenitor cells and tumor cells. Oligodendrocyte precursor cells (OPCs) are a population of NG2 expressing cells in the brain that accumulate in response to CNS injuries. OPCs, together with microglia and astrocytes, form the glial scar, which is believed to inhibit or prevent axonal regeneration partly by producing growth inhibiting NG2 at the injury site. It has been suggested that inhibiting NG2 at sites of spinal cord injury may increase beneficial axonal regeneration. Studies suggest that NG2 stimulates tumor growth and neovascularization in glioblastoma multiforme by inhibiting angiostatin and thus promoting angiogenesis. As NG2 is associated with increased tunmor cell proliferation, it may be a potential therapeutic marker in brain tumors.
Additional Text
Specificity
Recognizes rat Chondroitin Sulfate Proteoglycan at ~300kD. This antibody consists of a cocktail of four clones, and will react with the N-terminal domain of NG2, the central collagen binding domain and a membrane proximal epitope. Reactivity has been confirmed with rat B49 glial cell line. Species Crossreactivity: human
Purification
Protein A purified
Antibody Clonality
Monoclonal
C5067-71F-APC Datasheet
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