CLC5, Rat (Clcn5, Chloride Channel) Control Peptide

Catalogue Number: C5837-35-USB

Manufacturer:	United States Biological
Shelf Life:	12 months
Physical state:	Liquid
Type:	Control peptide
Host Cell:	Rat synthetic peptide
Shipping Condition:	Blue Ice
Unit(s):	100 ug
Application:	ELISA, WB

Overview
Datasheets

Additional Text

Caution

FOR RESEARCH USE ONLY

Specificity

A 13 AA Peptide sequence near the C-terminus of rat CLC-5. Chloride is a critical component of all living cells. Voltage-gated chloride channels regulate cellular traffic of chloride ion. The chloride channels (CIC or CLC) performs several functions including the regulation of cell volume, membrane potential stabilization, signal transduction and transepithelial transport. Mutations in CIC genes have been linked with several human diseases including myotonias (Thomsen's disease), cystic fibrosis, Bartters syndrome type III, Dent's disease and X-linked recessive nephrolithiasis. In mammals, CLC proteins form a superfamily of at least 9 different genes (CLC1-7 also known as CLCN1-7 and CLK1-2 or CLCKa and CLCKb). Additional forms of these proteins are obtained by alternative splicing. All CLC proteins (~700-1000 aa) are predicted to contain 10 (possibly 12) transmembrane domains.Except CLC-1 and CLC-K1/K2 that are specific for kidney, most other CLC are widely distributed in various tissues. rat CLC-5 is 746 aa membrane protein (human CLC-5 746) (1). CLC-5 is abundant in kidney moderate levels are found in the brain, lung and liver. Mutations or deletions in CLC-5 have been linked with Dent's diseases (excessive urinary calcium, urinary low mol wt proteinuria and calcium kidney stone) and four related X-linked syndromes of hypercalciuric nephrolithiasis

Purification

Purified

C5837-35 Datasheet

Price

£387.00

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