Claudin 7 (CLDN7) (APC)
Catalogue Number: C5838-54B-APC-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with Allophycocyanin (APC). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 6A45 |
| Isotype: | IgG2a, kappa |
| Immunogen: | Synthetic peptide corresponding to the C-terminal region of the human Claudin-7. |
| Application: | ELISA, IP, WB, IHC |
Description
Description: Claudin-7 is one of the transmembrane proteins that seal tight junctions and is critical for maintaining cell-to-cell adhesion in epithelial cell sheets. Claudin-7 is localized in the intercellular junctions of the epithelial cells of the proximal tubules of the nephrons in mammalian kidney. It is reportedly down-regulated in head and neck squamous cell carcinomas and loss of claudin-7 expression has been linked to histological grade in ductal carcinoma and invasive ductal carcinoma. Claudin-7 has been shown to regulate the expression of prostate-specific antigen (PSA) and it is also expressed in normal human and mouse epithelia.
Additional Text
Specificity
Recognizes human Claudin-7 at ~22kD. Does not cross-react with Claudin-3 or -4.
Purification
Protein A purified
Antibody Clonality
Monoclonal
C5838-54B-APC Datasheet
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