Clusterin (Clusterin Precursor, CLU, AAG4, Apolipoprotein J, APOJ, Apo-J, CLI, Complement-associated Protein SP-40, Complement Cytolysis Inhibitor, KUB1, MGC24903, NA1/NA2, SGP2, SGP-2, SP-40, Testosterone-repressed Prostate Message 2, TRPM2, TRPM-2) (Max

Catalogue Number: C5870-01G-ML490-USB

Manufacturer:	United States Biological
Physical state:	Supplied as a liquid in PBS, pH 7.2. Labeled with MaxLight™490.
Type:	Monoclonal Primary Antibody - Conjugated
Shipping Condition:	Blue Ice
Unit(s):	100 ul
Host name:	Mouse
Clone:	3R3/2
Isotype:	IgG1
Immunogen:	Glomerular basement membrane from a post-mortem kidney.
Application:	FC, WB, IHC, FLISA

Overview
Datasheets

Description

Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Clusterin is an ubiquitously expressed protein of two 40-kD chains, alpha and beta, covalently joined by disulfide bonds. It exists in two forms; a pro-apoptotic form localized to the nucleus and a pro-survival secreted form. Both are thought to be involved in DNA repair and cell cycle regulation. The secreted form is thought to inhibit apoptotic signalling by BAX, Clusterin suppression can sensitize cells to chemotherapy. Clusterin is overexpressed in human prostate cancer, breast cancers and squamous cell carcinomas. Part of the SC5b-9 complex, clusterin prevents the binding of a C5b-C7 complex to the membrane of the target cell inhibiting the complement cascade. Clusterin acts as an extracellular chaperone inhibiting the formation of human lysozyme amyloid associated with Alzheimer's disease. Clusterin is also important in spermatogenesis and is secreted by Sertoli cells.

Additional Text

Uniprot ID

P10909

Gene Name

CLU

Gene ID

1191

Specificity

Recognizes human Clusterin.

Purification

Protein A purified

Antibody Clonality

Monoclonal

Full Name

Clusterin (Clusterin Precursor, CLU, AAG4, Apolipoprotein J, APOJ, Apo-J, CLI, Complement-associated Protein SP-40, Complement Cytolysis Inhibitor, KUB1, MGC24903, NA1/NA2, SGP2, SGP-2, SP-40, Testosterone-repressed Prostate Message 2, TRPM2, TRPM-2) (MaxLight 490)

C5870-01G-ML490 Datasheet

Price

£1,096.00

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Quantity
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