Anti-Human CD16 [3G8] - Purified
Catalogue Number: C6850-LET
| Manufacturer: | Leinco Technologies, Inc |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 500 ug |
| Host name: | |
| Clone: | 3G8 |
| Isotype: | |
| Immunogen: | |
| Application: | FC, IHC-P, IP, MC |
Description
Description: CD16 antibody, 3G8, recognizes human CD16, also known as low-affinity IgG receptor III (FcγRIII). There are two distinct forms of CD16, CD16a (FcγRIIIa) and CD16b (FcγRIIIb). CD16a is a 50-65 kDa heterooligomeric polypeptide-anchored transmembrane protein expressed by NK cells, macrophages, and subsets of monocytes1. CD16b is a 48 kDa monomeric glycosylphosphatidylinositol (GPI)-anchored protein expressed on neutrophils1. Upon binding to the Fc portion of IgG or IgG-antigen complex, both CD16 isoforms induce signaling cascades resulting in multiple functions, including phagocytosis, cytokine release, proliferation, degranulation, and antibody dependent cell-mediated cytotoxicity (ADCC)2.
Additional Text
Concentration
0.5 mg/ml
Purification
Purified
Antibody Clonality
Monoclonal
Storage Note
This purified antibody is stable when stored at 2-8°C. Do not freeze.
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