Anti-Rat CD4 (Clone OX-38) - Purified in vivo GOLD™ Functional Grade
Catalogue Number: C752-LET
| Manufacturer: | Leinco Technologies, Inc |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg, 100 mg, 25 mg, 5 mg, 50 mg |
| Host name: | |
| Clone: | OX-38 |
| Isotype: | |
| Immunogen: | |
| Application: | ELISA, FC, IP, FA, Depl |
Description
Description: CD4 is a 55 kD single-chain type I transmembrane glycoprotein with four domains and is a member of the Ig superfamily1,2. CD4 functions primarily as a coreceptor for the MHC class II molecule-peptide complex and initiates the early phase of T-cell activation via its association with the T-cell receptor complex and protein tyrosine kinase Lck3. In addition, CD4 T lymphocytes are essential to the host response against infectious disease4 and CD4 T cells mediate neuronal damage in infectious and immune-mediated diseases of the central nervous system5. In macrophages and natural killer cells, CD4 plays a role in differentiation/activation, cytokine expression and cell migration3. OX-38 was generated by immunizing mice with lymphocytes or thymocyte glycoproteins and subsequently fusing mouse spleen cells with the P3-X63/Ag 8 cell line6. OX-38 is a depleting monoclonal antibody used to study tolerance to allografts7,8,9,10,11 , Pneumocystis-host interaction4, and alopecia12 in rat models.
Additional Text
Concentration
5 mg/ml
Purification
Purified
Antibody Clonality
Monoclonal
Storage Note
Functional grade preclinical antibodies may be stored sterile as received at 2-8°C for up to one month. For longer term storage, aseptically aliquot in working volumes without diluting and store at ≤ -70°C. Avoid Repeated Freeze Thaw Cycles.
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