Complement Factor B (C3/C5 Convertase, Glycine-rich beta Glycoprotein, GBG, PBF2, Properdin Factor B, CFB, BF, BFD, Complement Factor B Bb Fragment)
Catalogue Number: C7850-60P-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, 0.1% BSA, 0.02% sodium azide. |
| Type: | Monoclonal Primary Antibody - Unconjugated |
| Alias: | AHUS4|ARMD14|BF|B-factor, properdin|BFD|C3 proaccelerator|C3 proactivator|C3/C5 convertase|CFAB|CFBD|complement factor B|FB|FBI12|GBG|glycine-rich beta-glycoprotein|H2-Bf|PBF2|properdin factor B |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug |
| Host name: | Mouse |
| Clone: | M13/12 |
| Isotype: | IgG1 |
| Immunogen: | |
| Application: | ELISA, IP, WB |
Description
Description: Factor B is an acute-phase protein. Levels of factor B increase during inflammation. Complement factor B is a single-chain molecule of 764aa (MW of 90kD), including a leader peptide of 25aa. Factor B provides the catalytic subunit of the C3/C5 convertases of the alternative complement pathway. Assembly of the C3 convertase (C3bBb) requires binding of factor B to C3b (C3.H2O) and factor D-mediated cleavage of bound factor B resulting in the release of Ba (MW 33kD). The C3 convertase is stabilized by the binding of properdin. This provides a positive amplification loop for the classical and alternative complement pathways. Bb (MW 60kD) is the serine protease element of this convertase. After cleavage of C3, the C5 convertase ((C3b)2Bb) is formed. The Bb fragment may be regarded as a better indicator of the alternative pathway of complement activation than Ba as impaired renal filtration does directly influence Ba levels. Whereas Bb is elevated 2.2-fold in chronic renal failure (CRF) patients, plasma concentrations of Ba are 8.4-fold higher in CRF and 16-fold higher in end-stage renal disease (ESRD) patients compared to normals.
Additional Text
Caution
FOR RESEARCH USE ONLY
Gene Name
CFB
Uniprot ID
P00751
Gene ID
629
Specificity
Recognizes human complement factor B/Bb.
Purification
Protein G purified
Antibody Clonality
Monoclonal
C7850-60P Datasheet
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