Cortisol (APC)
Catalogue Number: C7904-03-APC-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. No stabilizing proteins added. Labeled with Allophycocyanin (APC). |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 4k3 |
| Isotype: | IgG1 |
| Immunogen: | Cortisol-3 (CMO), conjugated to BSA. |
| Application: | RIA, FLISA |
Description
Description: Cortisol is the most potent glucocorticoid produced by the human adrenal. It is synthesized from cholesterol and its production is stimulated by pituitary adrenocorticotropic hormone (ACTH) which is regulated by corticotropin releasing factor (CRF). ACTH and CRF secretions are inhibited by high cortisol levels in a negative feedback loop. In plasma a majority of cortisol is bound with high affinity to corticosteroid binding globulin (CBG or transcotin). Cortisol acts through specific intracellular receptors and affects numerous physiologic systems including immune function, glucose counter regulation, vascular tone, and bone metabolism.
Additional Text
Specificity
Recognizes Cortisol-BSA conjugate and free cortisol. Does not crossreact with BSA. Crossreactivity (50% displacement of cortisol-3-125-Iodine): Cortisol: 100%; Cortisone: 30%; Corticosterone: 20%; 17-Hydroxyprogesterone: 0%.
Purification
Protein G purified
Antibody Clonality
Monoclonal
C7904-03-APC Datasheet
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