Cortisol (MaxLight 490)
Catalogue Number: C7904-11B-ML490-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 8.F.57B |
| Isotype: | IgG2a |
| Immunogen: | Cortisol 3 conjugated to BSA. |
| Application: | RIA, FLISA |
Description
Description: MaxLight™ 490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Cortisol is a corticosteroid hormone produced by the adrenal cortex that is involved in the response to stress; it increases blood pressure, blood sugar levels, may cause infertility in women, and suppresses the immune system. Synthetic cortisol, also known as hydrocortisone, is used as a drug mainly to fight allergies and inflammation. Cortisol is synthesized from pregnenolone. The conversion involves hydroxylation of C-11, C-17, and C-21, the oxidation of C-3, and the isomerization of the C-5 double bond to C-4. The synthesis takes place in the zona fasciculata of the cortex of the adrenal glands.
Additional Text
Specificity
Recognizes Cortisol 3. Crossreactivity (RIA): Cortisol: 100%; Prednisolone: 5.1%; 11-Deoxycortisol: 0.6%; Corticosterone: 0.3%; Testosterone, Estradiol, 17-OH-Progesterone, Progesterone, 11-Deoxycorticosterone: <0.1%.
Purification
Protein A purified
Antibody Clonality
Monoclonal
C7904-11B-ML490 Datasheet
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