Cyclin E (MaxLight 650)
Catalogue Number: C8455-21-ML650-USB
| Manufacturer: | United States Biological |
| Physical state: | Supplied as a liquid in PBS, pH 7.2. No preservatives added. Labeled with MaxLight™650. |
| Type: | Monoclonal Primary Antibody - Conjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul |
| Host name: | Mouse |
| Clone: | 3G116 |
| Isotype: | IgG2b, kappa |
| Immunogen: | Full-length recombinant protein corresponding to human cyclin E. |
| Application: | ICC, IF, IP, WB |
Description
Description: MaxLight™ 650 is a new Far-IR stable dye conjugate comparable to Alexa Fluor™647, DyLight™649, Cy5™ and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (655nm); Emission (676nm); Extinction Coefficient 250,000. Cyclin E is a cell cycle protein, 50kD, that complexes with cdk2 and is required for DNA synthesis. Cyclin E/cdk2 activity peaks just before S phase. Cyclin E expression is mediated by E2F and is cleared by the ubiquitin proteolytic pathway after phosphorylation. Alterations in cyclin E expression in cancer has been correlated with increasing stage and grade of tumor. These results suggest that cyclin E may be useful as a prognostic marker for breast cancer and gastric cancer, and non-small cell lung cancer.
Additional Text
Specificity
Recognizes human cyclin E. The epitope is located within the last 80aa of the C-terminal. Detects a ~50kD band on human HeLa cell lysates by Western Blot analysis.
Purification
Protein A purified
Antibody Clonality
Monoclonal
C8455-21-ML650 Datasheet
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