Cytokeratin 7 (MaxLight 490)

Catalogue Number: C9097-40F-ML490-USB

Manufacturer:United States Biological
Physical state:Supplied as a liquid in PBS, pH 7.2. No preservative added. Labeled with MaxLight™490.
Type:Monoclonal Primary Antibody - Conjugated
Alias:CD20|CK20|CK-20|cytokeratin 20|K20|keratin 20, type I|keratin, type I cytoskeletal 20|KRT21|protein IT
Shipping Condition:Blue Ice
Unit(s): 100 ul
Host name: Mouse
Clone: 2Q1133 (OV-TL 12/30)
Isotype: IgG1
Immunogen: Cytoskeletal preparation of OTN-11 ovarian carcinoma cell line.
Application: FC, ICC, WB, IHC

Description

Description: MaxLight™490 is a new Blue-Green photostable dye conjugate comparable to DyLight™488, Alexa Fluor™488 and offers better labeling efficiency, brighter imaging and increased immunodetection. Absorbance (491nm); Emission (515nm); Extinction Coefficient 73,000. Cytokeratins are a subfamily of intermediate filament proteins and are characterized by a remarkable biochemical diversity, represented in epithelial tissues by at least 20 different polypeptides. They range in molecular weight between 40kD and 68kD and isoelectric pH between 4.9-7.8. The individual cytokeratin polypeptides are designated 1 to 20. The various epithelia in the human body usually express cytokeratins which are not only characteristic of the type of epithelium, but also related to the degree of maturation or differentiation within an epithelium. Cytokeratin subtype expression patterns are used to an increasing extent in the distinction of different types of epithelial malignancies. The cytokeratin antibodies are not only of assistance in the differential diagnosis of tumors using immunohistochemistry on tissue sections, but are also a useful tool in cytopathology and flow cytometric assays.

Additional Text

Gene ID

54474

Gene Name

KRT20

Uniprot ID

P35900

Specificity

Recognizes human cytokeratin 7. Reacts with specific glandular-type epithelia and most carcinomas derived from them.

Purification

Purified

Antibody Clonality

Monoclonal