Biotinylated Human CD20/MS4A1 Protein-Nanodisc (CD2-HM12NB)
Catalogue Number: CD2-HM12NB-KAT
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CD2-HM12NB Image
CD2-HM12NB Image
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Biotinylated Human CD20 Nanodisc captured on CM5 Chip via Streptavidin can bind Rituximab, hFc Tag with an affinity constant of 10.21 nM as determined in SPR assay (Biacore T200).
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Immobilized Biotinylated Human CD20 Nanodisc, His Tag at 2ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Ofatumumab, hFc Tag with the EC50 of 30.8ng/ml determined by ELISA.
CD2-HM12NB Image
Immobilized Biotinylated Human CD20 Nanodisc, His Tag at 2ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Rituximab, hFc Tag with the EC50 of 0.16ug/ml determined by ELISA.
CD2-HM12NB Image
Immobilized Biotinylated Human CD20 Nanodisc, His Tag at 2ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Obinutuzumab, hFc Tag with the EC50 of 7.9ng/ml determined by ELISA.
CD2-HM12NB Image
Loaded Biotinylated Human CD20 Nanodisc, His Tag on Streptavidin-Biosensor can bind Rituximab, hFc Tag with an affinity constant of 6.94 nM as determined in BLI assay (Gator® Prime).
| Manufacturer: | Kactus |
| Shelf Life: | 6 months |
| Molecular Weight: | The protein has a predicted MW of 46.0 kDa. |
| Physical state: | Liquid |
| Type: | Protein - Conjugated |
| Alias: | MS4A1; CD20; MS4A-1; B1; Bp35; CD20 receptor; CD20S7; CVID5; LEU-16; Ly-44; MS4A2; S7 |
| Host Cell: | HEK293 cells |
| Shipping Condition: | Dry Ice |
| Unit(s): | 100 ug |
Description
Description: B-lymphocyte antigen CD20 or CD20 is an activated-glycosylated phosphoprotein expressed on the surface of all B-cells beginning at the pro-B phase (CD45R , CD117) and progressively increasing in concentration until maturity.CD20 is the target of the monoclonal antibodies rituximab, ocrelizumab, obinutuzumab, ofatumumab, ibritumomab tiuxetan, tositumomab, and ublituximab, which are all active agents in the treatment of all B cell lymphomas, leukemias, and B cell-mediated autoimmune diseases.
Additional Text
Protein Tag
HIS Tag
Storage Note
Valid for 6 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
UniProt ID
P11836-1
Endotoxin
Less than 1 EU per µg by the LAL method.
Short Description
Recombinant Biotinylated Human CD20/MS4A1 Protein-Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Pro297.
CD2-HM12NB Datasheet
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