Biotinylated Human CD96/TACTILE Protein (CD9-HM496B)

Catalogue Number: CD9-HM496B-KAT

Manufacturer:	Kactus
Shelf Life:	12 months
Molecular Weight:	The protein has a predicted MW of 59.1 kDa. Due to glycosylation, the protein migrates to 90-140 kDa based on Bis-Tris PAGE result.
Physical state:	Lyophilized
Type:	Protein - Conjugated
Alias:	CD96 molecule; CD96; DKFZp667E2122; TACTILE
Host Cell:	HEK293 cells
Shipping Condition:	RT
Unit(s):	100 ug, 500 ug
Application:	ELISA, WB

Overview
Datasheets

Description

Description: The receptors CD96 and TIGIT are expressed on the surface of T and natural killer (NK) cells, and recent studies suggest both play important inhibitory roles in immune function. CD96 has been shown to modulate immune cell activity in mice, with Cd96-/- mice displaying hypersensitive NK-cell responses to immune challenge and significant tumor resistance. The counterbalance between the putative inhibitory CD96 and TIGIT receptors and the activating receptor, CD226, offers unique strategies for immuno-oncology drug development.

Additional Text

Uniprot ID

P40200-2

Protein Tag

HIS-AviTag™

Short Description

Recombinant Biotinylated Human CD96/TACTILE Protein is expressed from HEK293 with His tag and Avi tag at the C-Terminus.It contains Val22-Met503.

Storage Note

-20 to -80°C for 12 months as supplied from date of receipt.; -80°C for 3 months after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.

Biological Activity

Immobilized Anti-CD96 Antibody, hFc Tag at 1Oeg/ml (100Oel/well) on the plate. Dose response curve for Biotinylated Human CD96, His Tag with the EC50 of 0.55ug/ml determined by ELISA. See testing image for detail.

Endotoxin

Less than 1 EU per µg by the LAL method.

CD9-HM496B Datasheet

CD9-HM496B MSDS

Price

£413.00

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