Human CDH17/Cadherin 17 Protein (CDH-HM217)
Catalogue Number: CDH-HM217-KAT
CDH-HM217 Image
CDH-HM217 Image
CDH-HM217 Image
CDH-HM217 Image
CDH-HM217 Image
The purity of Human CDH17 is greater than 95% as determined by SEC-HPLC.
CDH-HM217 Image
Human CDH17 on Bis-Tris PAGE under reduced condition. The purity is greater than 95%.
CDH-HM217 Image
Immobilized Human CDH17, hFc Tag at 0.5ug/ml (100ul/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Antibody, hFc Tag with the EC50 of 8.6ng/ml determined by ELISA.
CDH-HM217 Image
Loaded Biotinylated Anti-CDH17 Antibody, hFc-Avi Tag on Streptavidin-Biosensor can bind Human CDH17, hFc Tag with an affinity constant of 0.14 nM as determined in BLI assay (Gator® Prime).
| Manufacturer: | Kactus |
| Shelf Life: | 12 months |
| Molecular Weight: | The protein has a predicted MW of 111.73 kDa. Due to glycosylation, the protein migrates to 113-135 kDa based on Bis-Tris PAGE result. |
| Physical state: | Lyophilized |
| Type: | Other Recombinant Protein |
| Alias: | Cadherin-17; BILL-cadherin; LI-cadherin; P130; Cdh17; CDH16; HPT-1; cadherin-16; FLJ26931; MGC138218; MGC142024 |
| Host Cell: | HEK293 cells |
| Shipping Condition: | RT |
| Unit(s): | 100 ug, 500 ug |
| Application: | ELISA, WB |
Description
Description: Liver-intestine cadherin (CDH17) has been known to function as a tumor stimulator and diagnostic marker for almost two decades.In vivo studies showed CDH17 knockout resulted in apoptotic PC tumor death through activating caspase-3 activity. Taken together, CDH17 functions as an oncogenic molecule critical to PC growth by regulating tumor apoptosis signaling pathways and CDH17 could be targeted to develop an anti-PC therapeutic approach.
Additional Text
Gene Name
CDH17
Gene ID
1015
Uniprot ID
Q12864
Protein Tag
hFC Tag
Short Description
Recombinant Human CDH17/Cadherin 17 Protein is expressed from HEK293 with hFc tag at the C-Terminus.It contains Gln23-Met787.
Storage Note
-20 to -80°C for 12 months as supplied from date of receipt.; -80°C for 3 months after reconstitution.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Biological Activity
Immobilized Human CDH17, hFc Tag at 0.5Oeg/ml (100Oel/well) on the plate. Dose response curve for Biotinylated Anti-CDH17 Antibody, hFc Tag with the EC50 of 14.8ng/ml determined by ELISA. See testing image for detail.
Endotoxin
Less than 1 EU per µg by the LAL method.
CDH-HM217 Datasheet
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