Biotinylated Human Claudin 4 Protein-Nanodisc (CLD-HM14NB)
Catalogue Number: CLD-HM14NB-KAT
CLD-HM14NB Image
CLD-HM14NB Image
CLD-HM14NB Image
Biotinylated Human Claudin 4 Nanodisc, His Tag captured on CM5 Chip via Streptavidin can bind Anti-Claudin 4 Antibody, hFc Tag with an affinity constant of 6.145 nM as determined in SPR assay (Biacore T200).
CLD-HM14NB Image
Immobilized Biotinylated Human Claudin 4 Nanodisc, His Tag at 5ug/ml (100ul/well) on the streptavidin precoated plate (5ug/ml). Dose response curve for Anti-Claudin 4 Antibody, hFc Tag with the EC50 of 6.6ng/ml determined by ELISA (QC Test).
| Manufacturer: | Kactus |
| Shelf Life: | 6 months |
| Molecular Weight: | The protein has a predicted MW of 35.0 kDa. |
| Physical state: | Liquid |
| Type: | Protein - Conjugated |
| Alias: | Claudin-4; CLDN4; Claudin4; CPE-R; CPE R; CPETR1; WBSCR8 |
| Host Cell: | HEK293 cells |
| Shipping Condition: | Dry Ice |
| Unit(s): | 100 ug |
Description
Description: Claudin-4 (CLDN4) is a key component of tight junctions (TJs) in epithelial cells. CLDN4 is overexpressed in many epithelial malignancies and correlates with cancer progression. Changes in CLDN4 expression have been associated with epigenetic factors (such as hypomethylation of promoter DNA), inflammation associated with infection and cytokines, and growth factor signaling. CLDN4 helps to maintain the tumor microenvironment by forming TJs and acts as a barrier to the entry of anticancer drugs into tumors.
Additional Text
Gene ID
1364
Gene Name
CLDN4
Uniprot ID
O14493
Protein Tag
HIS Tag
Storage Note
Valid for 6 months from date of receipt when stored at -80°C.; Recommend to aliquot the protein into smaller quantities for optimal storage. Please minimize freeze-thaw cycles.
Endotoxin
Less than 1 EU per µg by the LAL method.
Short Description
Recombinant Biotinylated Human Claudin 4 Protein-Nanodisc is expressed from HEK293 with His tag at the C-terminus.It contains Met1-Val209.
CLD-HM14NB Datasheet
SUPPORT
outstanding technical support
PRODUCT
we offer a full product guarantee
DELIVERY
we offer free delivery to UK universities and non profit organisations