5-Vinyl-2'-deoxyuridine (5-VdU), 5-Ethenyl-2'-deoxyuridine
Catalogue Number: CLK-050-50-JEN
| Manufacturer: | Jena Bioscience |
| Shelf Life: | 12 months |
| Physical state: | solid |
| Type: | Conjugation Reagent |
| Shipping Condition: | RT |
| Unit(s): | 50 mg |
Description
Description: 5-VdU (5-Vinyl-2'-deoxyuridine) can be used as a replacement for BrdU (5-Bromo-2'-deoxyuridine) or the copper-catalyst requiring 5-EdU (5-Ethynyl-2'-deoxyuridine) to measure de novo DNA synthesis during the S-phase of the cell cycle. 5-VdU is cell permeable and incorporates into replicating DNA instead of its natural analog thymidine. The resulting vinyl-functionalized DNA can subsequently be detected via Cu(I)-free Alkene-Tetrazine Ligation that offers the choice to introduce a Biotin group (via Tetrazines of Biotin) for subsequent purification tasks or a fluorescent group (via Tetrazines of fluorescent dyes) for subsequent microscopic imaging [1].
Additional Text
Solubility
DMSO, methanol
Application Notes
DNA synthesis monitoring[1]
Short Description
2'-Deoxy-5-vinyluridine 2'-Deoxy-5-ethenyluridine
Smile String
n1(cc(c(=O)[nH]c1=O)C=C)[C@H]1C[C@@H]([C@H](O1)CO)O
CLK-050-50 MSDS
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