THPTA, Tris((1-hydroxy-propyl-1H-1,2,3-triazol-4-yl)methyl)amine
Catalogue Number: CLK-1010-100-JEN
| Manufacturer: | Jena Bioscience |
| Shelf Life: | 12 months |
| Physical state: | solid |
| Type: | Conjugation Reagent |
| Shipping Condition: | RT |
| Storage Condition: | 2-8°C |
| Unit(s): | 100 mg |
Description
Description: THPTA is a water-soluble, very effective ligand for Cu(I)-catalyzed Alkyne-Azide click chemistry reactions (CuAAC). It serves a dual purpose: 1) Accelaration of the CuAAC reaction by maintaining the Cu(I) oxidation state of copper sources and 2) Protection of biomolecules from oxidative damage during the labeling reaction[1,2]. THPTA is a superior alternative to water-insoluble TBTA. A stock solution can be prepared in ddH2O and subsequently be stored at -20°C. Avoid freeze-thaw cycles. Presolski et al.[1] and Hong et al.[2] provide a general protocol for CuAAC reactions that may be used as a starting point for the set up and optimization of individual assays.
Additional Text
Solubility
water, DMSO, DMF, MeOH
Smile String
N(Cc1nnn(c1)CCCO)(Cc1nnn(c1)CCCO)Cc1cn(nn1)CCCO
CLK-1010-100 MSDS
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