Collagen Type I, human
Catalogue Number: CO20111-0.1-NMB
| Manufacturer: | Nordic MuBio |
| Type: | Primary Antibody |
| Shipping Condition: | RT |
| Unit(s): | 0.1 ml |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | |
| Immunogen: | Purified collagen type I from human skin |
| Application: | ELISA, IF, IHC-P, WB, RIA |
Description
Description: Type I Collagen usually exists as a heterotrimer formed by alpha 1(I) and alpha 2(I) chains and is found in bone, cornea, skin and tendon. In foetal tissues also homotrimers of alpha-1(I) are found, but they are not constituents of normal adult tissues. Collagens consist of a family of highly specialized glycoproteins of which at least 16 genetically distinct types are known to date. The basal unit of a collagen molecule consists of a triple-helical structure formed by 3 alpha-chains. Predominant amino acids are glycine, proline and hydroxproline. Regularly also lysines and hydroxylysines occur, which are responsible for cross-linkage and glycosylation of the protein chains. Different composition of alpha-chains and different glycosylation contribute to the high variability of collagens in different tissues and organs. Human collagen type I, cross-reactivity with collagen type II and IV <0.1%, collagen type III and V <1.0%, human fibronectin and laminin <0.1%, mouse laminin <0.1% (RIA at a 1:500 dilution).
Additional Text
Gene Name
COL1A1
Uniprot ID
P02452
Concentration
0.5 mg/ml
Gene ID
1277
Purification
Affinity Purified
Storage Note
-20°C
Application Notes
IHC(P), IFA, ELISA, RIA, IB/WB
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