Recombinant Human Kit ligand protein (KITLG), partial (Active)

Catalogue Number: CSB-AP002061HU-CSB

Manufacturer:Cusabio Biotech
Shelf Life:6 months
Molecular Weight:18.5 kDa
Physical state:Lyophilized
Type:Other Recombinant Protein
Alias:Mast cell growth factor, Stem cell factor, SCF, c-Kit ligand
Host Cell:E.coli
Shipping Condition:Blue Ice
Unit(s): 10 ug, 100 ug, 500 ug

Description

Description: Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis. KITLG/SCF binding can activate several signaling pathways. Promotes phosphorylation of PIK3R1, the regulatory subunit of phosphatidylinositol 3-kinase, and subsequent activation of the kinase AKT1. KITLG/SCF and KIT also transmit signals via GRB2 and activation of RAS, RAF1 and the MAP kinases MAPK1/ERK2 and/or MAPK3/ERK1. KITLG/SCF and KIT promote activation of STAT family members STAT1, STAT3 and STAT5. KITLG/SCF and KIT promote activation of PLCG1, leading to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. KITLG/SCF acts synergistically with other cytokines, probably interleukins.

Additional Text

Gene Name

KITLG

Gene ID

4254

Uniprot ID

P21583

Protein Tag

Untagged

Storage Note

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Price
£227.00


Find out about delivery

SUPPORT

outstanding technical support

PRODUCT

we offer a full product guarantee

DELIVERY

we offer free delivery to UK universities and non profit organisations