Recombinant Human 5'-nucleotidase(NT5E),partial

Catalogue Number: CSB-AP005071HU-CSB

Manufacturer:Cusabio Biotech
Type:Bioactive Proteins
Alias:5'-Nucleotidase; 5'-NT; Ecto-5'-Nucleotidase; CD73; NT5E; NT5; NTE
Host Cell:Mammalian cell
Shipping Condition:Blue Ice
Unit(s): 50 ug, 10 ug, 1 mg, 500 ug
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Isotype:
Immunogen:

Description

Description: CD73 is a glycosyl phosphatidylinositol (GPI) anchored membrane protein that belongs to the 5'-nucleotidase family. CD73 is an ecto 5'Nucleotidase expressed by most cell types. CD73 hydrolyzes extracellular nucleotides into membrane permeable nucleosides. CD73 is one of several enzymes responsible for the production of extracellular adenosine, a signaling molecule that is involved in responses to inflammation and tissue injury. CD73 is a lymphocyte maturation marker that has functions independent of its catalytic activity. CD73 is also a regulator of leukocyte extravasation, a function that requires its 5'Nucleotidase activity. Defects in NT5E are the cause of calcification of joints and arteries (CAJA). The recombinant CD73 lacking GPI anchor is secreted as a monomer.

Additional Text

Gene Name

NT5E

Biological Activity

Specific activity as determined by its ability to hydrolyze the 5’-phosphate group from the substrate adenosine-5’-monophosphate (AMP) is greater than 15000 pmol/min/µg. The orthophosphate product is measured by a malachite green phosphate detection kit.

Endotoxin

Less than 1.0 EU/µg as determined by LAL method.

Function

Hydrolyzes extracellular nucleotides into membrane permeable nucleosides. Exhibits AMP-, NAD-, and NMN-nucleosidase activities.

OMIN ID

129190

Protein : Gene Alias

5'-Nucleotidase; 5'-NT; Ecto-5'-Nucleotidase; CD73; NT5E; NT5; NTE

Protein : TAG

6xHIS Tag

Price
449.00


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