Recombinant Human Nectin-2 (NECTIN2), partial (Active)

Catalogue Number: CSB-AP005081HU-CSB

Manufacturer:	Cusabio Biotech
Shelf Life:	6 months
Molecular Weight:	36.58 kDa
Physical state:	Lyophilized
Type:	Bioactive Proteins
Alias:	Poliovirus Receptor-Related Protein 2; Herpes Virus Entry Mediator B; Herpesvirus Entry Mediator B; HveB; Nectin-2; CD112; PVRL2; HVEB; PRR2
Host Cell:	Mammalian Cells
Shipping Condition:	Blue Ice
Unit(s):	50 ug, 10 ug, 1 mg, 500 ug
Host name:
Clone:
Isotype:
Immunogen:

Overview
Datasheets

Description

Description: CD112 is a type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. It comprises one Ig-like V-type domain and two Ig-like C2-type domains in the extracellular region. The V domain is believed to mediate nectin binding to its ligands. Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), involving in cell to cell spreading of these viruses. It does not bind poliovirus. As a homophilic adhesion molecule, CD112 is found concentrated in adherens junctions, and exists on neurons, endothelial cells,epithelial cells and fibroblasts. CD112 has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 mediates cytotoxicity and cytokine secretion by T and NK cells. The costimulatory responses may be a critical component in allergic reactions and may therefore become targets for anti-allergic therapy.

Additional Text

Function

Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive

Protein Tag

6xHIS Tag

Uniprot ID

Q92692-2

Storage Note

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

CSB-AP005081HU Sequence

CSB-AP005081HU MSDS

Price

£273.00

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