Recombinant Human Nectin-2(NECTIN2),partial

Catalogue Number: CSB-AP005081HU-CSB

Manufacturer:Cusabio Biotech
Type:Bioactive Proteins
Alias:Poliovirus Receptor-Related Protein 2; Herpes Virus Entry Mediator B; Herpesvirus Entry Mediator B; HveB; Nectin-2; CD112; PVRL2; HVEB; PRR2
Host Cell:Mammalian cell
Shipping Condition:Blue Ice
Unit(s): 50 ug, 10 ug, 1 mg, 500 ug
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Immunogen:

Description

Description: CD112 is a type I transmembrane glycoprotein belonging to the Immunoglobulin superfamily. It comprises one Ig-like V-type domain and two Ig-like C2-type domains in the extracellular region. The V domain is believed to mediate nectin binding to its ligands. Nectin2 is known to bind the pseudorabies virus, and herpes simplex virus2 (HSV2), involving in cell to cell spreading of these viruses. It does not bind poliovirus. As a homophilic adhesion molecule, CD112 is found concentrated in adherens junctions, and exists on neurons, endothelial cells,epithelial cells and fibroblasts. CD112 has been identified as the ligand for DNAM-1 (CD226), and the interaction of CD226/CD112 mediates cytotoxicity and cytokine secretion by T and NK cells. The costimulatory responses may be a critical component in allergic reactions and may therefore become targets for anti-allergic therapy.

Additional Text

Biological Activity

The ED50 as determined by its ability to bind Human DNAM-1 in functional ELISA is less than 10 ug/ml.

Endotoxin

Less than 1.0 EU/µg as determined by LAL method.

Function

Modulator of T-cell signaling. Can be either a costimulator of T-cell function, or a coinhibitor, depending on the receptor it binds to. Upon binding to CD226, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Upon interaction with PVRIG, inhibits T-cell proliferation. These interactions are competitive

Gene Name

NECTIN2

OMIN ID

600798

Protein : Gene Alias

Poliovirus Receptor-Related Protein 2; Herpes Virus Entry Mediator B; Herpesvirus Entry Mediator B; HveB; Nectin-2; CD112; PVRL2; HVEB; PRR2

Protein : TAG

6xHIS Tag

Price
224.00


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