Recombinant Human Lysosome-associated membrane glycoprotein 1(LAMP1),partial (Active)
Catalogue Number: CSB-AP005091HU-CSB
| Manufacturer: | Cusabio Biotech |
| Shelf Life: | 6 months |
| Molecular Weight: | 65.5 kDa |
| Physical state: | Lyophilized |
| Type: | Bioactive Proteins |
| Alias: | Lysosome-Associated Membrane Glycoprotein 1; LAMP-1; Lysosome-Associated Membrane Protein 1; CD107 Antigen-Like Family Member A; CD107a; LAMP1 |
| Host Cell: | Mammalian Cells |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug, 10 ug, 1 mg, 500 ug |
Description
Description: Lysosome-Associated Membrane Glycoprotein 1 (LAMP1) is a single-pass type I membrane protein belonging to the LAMP family. LAMP1 is expressed largely in the endosome-lysosome membranes of cells.It shuttles between lysosomes, endosomes, and the plasma membrane. LAMP1 functions to present carbohydrate ligands to selectins and it has also been implicated in tumor cell metastasis. It has been proposed LAMP1 can be used as a therapeutic agent for certain cancers, as well as a marker for lysosomal storage disorders and degranulation on lymphocytes such as CD8+ and NK cells. Cell surface LAMP1 and LAMP2 have been shown to promote adhesion of human peripheral blood mononuclear cells(PBMC) to vascular endothelium, therefore they are possibly involved in the adhesion of PBMCs to the site of inflammation.
Additional Text
Uniprot ID
P11279
Biological Activity
The ED50 as determined by its ability to bind Human Galectin-3 in functional ELISA is less than 20 ng/ml.
Endotoxin
Less than 1.0 EU/µg as determined by LAL method.
Function
Presents carbohydrate ligands to selectins. Also implicated in tumor cell metastasis.; FUNCTION
Protein Tag
Fc Tag
OMIN ID
153330
CSB-AP005091HU Sequence
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
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