Recombinant Human Tumor necrosis factor receptor superfamily member 4 (TNFRSF4), partial (Active)
Catalogue Number: CSB-AP005251HU-CSB
| Manufacturer: | Cusabio Biotech |
| Shelf Life: | 6 months |
| Molecular Weight: | 46.8 kDa |
| Physical state: | Lyophilized |
| Type: | Bioactive Proteins |
| Alias: | Tumor necrosis factor receptor superfamily member 4;ACT35 antigen;OX40L receptor;TAX transcriptionally-activated glycoprotein 1 receptor;TNFRSF4;OX40;CD134;Txgp1 |
| Host Cell: | Mammalian Cells |
| Shipping Condition: | Blue Ice |
| Unit(s): | 50 ug, 10 ug, 1 mg, 500 ug |
Description
Description: OX40,also termed CD134 and TNFRSF4, is a T cell co-stimulatory molecule of the TNF receptor superfamily which plays a key role in the survival and homeostasis of effector and memory T cells. OX40 is expressed on CD4+ and CD8+ T cells upon engagement of the TCR by antigen presenting cells along with co-stimulation by CD40-CD40 Ligand and CD28-B7. The interaction between OX40 and OX40 ligand (OX40L) will occur when activated T cells bind to professional antigen-presenting cells (APCs). The T-cell functions, including cytokine production, expansion, and survival, are then enhanced by the OX40 costimulatory signals. OX40 signals are critical for controlling the function and differentiation of Foxp3+ regulatory T cells. OX40-OX40L interaction regulates T-cell tolerance, peripheral T-cell homeostasis, and T-cell-mediated inflammatory diseases.
Additional Text
Gene Name
TNFRSF4
Gene ID
7293
Uniprot ID
P43489
Biological Activity
The ED50 as determined by its ability to bind Human TNFSF4 in functional ELISA is less than 10 ug/ml.
Endotoxin
Less than 1.0 EU/µg as determined by LAL method.
Function
Receptor for TNFSF4/OX40L/GP34. Is a costimulatory molecule implicated in long-term T-cell immunity.
Protein Tag
Fc Tag
Storage Note
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
CSB-AP005251HU Sequence
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DELIVERY
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