Recombinant Murine polyomavirus Major capsid protein VP1

Catalogue Number: CSB-BP326154MKK-CSB

Manufacturer:	Cusabio Biotech
Shelf Life:	6 months
Molecular Weight:	42.5 kda
Physical state:	Liquid or Lyophilized powder
Type:	Virus Proteins
Alias:	Major structural protein VP1
Host Cell:	Baculovirus
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 20 ug, 1 mg
Host name:
Clone:
Isotype:
Immunogen:

Overview
Datasheets

Description

Description: Forms an icosahedral capsid with a T=7 symmetry and a 40 nm diameter. The capsid is composed of 72 pentamers linked to each other by disulfide bonds and associated with VP2 or VP3 proteins. Interacts with terminal alpha(2,3)-linked sialic acids on the cell surface to provide virion attachment to target cell. This attachment induces virion internalization predominantly through caveolin-mediated endocytosis. Once attached, the virion is internalized by caveolin-mediated endocytosis and traffics to the endoplasmic reticulum. Inside the endoplasmic reticulum, the protein folding machinery isomerizes VP1 interpentamer disulfide bonds, thereby triggering initial uncoating. Next, the virion uses the endoplasmic reticulum-associated degradation machinery to probably translocate in the cytosol before reaching the nucleus. Nuclear entry of the viral DNA involves the selective exposure and importin recognition of VP2/Vp3 nuclear localization signal. In late phase of infection, neo-synthesized VP1 encapsulates replicated genomic DNA in the nucleus, and participates in rearranging nucleosomes around the viral DNA.

Additional Text

Protein Tag

6xHIS Tag

Uniprot ID

P24595

Storage Note

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

Gene ID

29031028

Gene Name

VP1

CSB-BP326154MKK MSDS

Price

£947.00

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