Recombinant Human 5-hydroxytryptamine receptor 1B(HTR1B)

Catalogue Number: CSB-CF010882HUB2-CSB

Manufacturer:Cusabio Biotech
Shelf Life:6 months
Molecular Weight:62.1 kDa
Physical state:Liquid or Lyophilized powder
Type:Bioactive Proteins
Alias:S12 Serotonin 1D beta receptor
Host Cell:E.coli
Shipping Condition:Blue Ice
Unit(s): 100 ug, 20 ug


Description: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for ergot alkaloid derivatives, various anxiolytic and antidepressant drugs and other psychoactive substances, such as lysergic acid diethylamide (LSD). Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.

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