Recombinant Human 5-hydroxytryptamine receptor 2B(HTR2B)

Catalogue Number: CSB-CF010888HU-CSB

Manufacturer:	Cusabio Biotech
Shelf Life:	6 months
Molecular Weight:	70.3 kDa
Physical state:	Liquid or Lyophilized powder
Type:	Fusion Protein
Alias:	Serotonin receptor 2B
Host Cell:	E.coli
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 20 ug

Overview

Description

Description: G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various ergot alkaloid derivatives and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Beta-arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Signaling activates a phosphatidylinositol-calcium second messenger system that modulates the activity of phosphatidylinositol 3-kinase and down-stream signaling cascades and promotes the release of Ca2+ ions from intracellular stores. Plays a role in the regulation of dopamine and 5-hydroxytryptamine release, 5-hydroxytryptamine uptake and in the regulation of extracellular dopamine and 5-hydroxytryptamine levels, and thereby affects neural activity. May play a role in the perception of pain. Plays a role in the regulation of behavior, including impulsive behavior. Required for normal proliferation of embryonic cardiac myocytes and normal heart development. Protects cardiomyocytes against apoptosis. Plays a role in the adaptation of pulmonary arteries to chronic hypoxia. Plays a role in vasoconstriction. Required for normal osteoblast function and proliferation, and for maintaining normal bone density. Required for normal proliferation of the interstitial cells of Cajal in the intestine.

Additional Text

Uniprot ID

P41595

OMIN ID

601122

Protein Tag

6xHIS-SUMO Tag

Price

£2,354.00

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