Recombinant Human Arachidonate 12-lipoxygenase, 12S-type(ALOX12)
Catalogue Number: CSB-EP001617HU-CSB
| Manufacturer: | Cusabio Biotech |
| Shelf Life: | 6 months |
| Molecular Weight: | 79.8 kDa |
| Physical state: | Liquid or Lyophilized powder |
| Type: | Other Enzymes |
| Alias: | Lipoxin synthase 12-LO (EC:3.3.2.-) (Platelet-type lipoxygenase 12) (12S-LOX) (12S-lipoxygenase) (12LO) (LOG12) |
| Host Cell: | E.coli |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg, 100 ug, 20 ug |
Description
Description: Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to-hydroperoxyeicosatetraenoic acid/-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.
Additional Text
Uniprot ID
P18054
Protein Tag
6xHIS Tag
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