Recombinant Sheep Interleukin-12 subunit beta(IL12B)
Catalogue Number: CSB-EP011587SH-CSB
| Manufacturer: | Cusabio Biotech |
| Shelf Life: | 6 months |
| Molecular Weight: | 38.5 kDa |
| Physical state: | Liquid or Lyophilized powder |
| Type: | Interleukins |
| Alias: | Cytotoxic lymphocyte maturation factor 40KDA subunit ;CLMF p40IL-12 subunit p40 |
| Host Cell: | E.coli |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg, 100 ug, 20 ug |
Description
Description: Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC.Associates with IL23A to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates mory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tumorigenesis .
Additional Text
Uniprot ID
P68220
Protein Tag
6xHIS Tag
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