Recombinant Mouse Importin subunit beta-1(Kpnb1)

Catalogue Number: CSB-EP012490MO-CSB

Manufacturer:	Cusabio Biotech
Shelf Life:	6 months
Molecular Weight:	101.2 kDa
Physical state:	Liquid or Lyophilized powder
Type:	Fusion Protein
Alias:	Karyopherin subunit beta-1Nuclear factor p97Pore targeting complex 97KDA subunit ;PTAC97SCG
Host Cell:	E.coli
Shipping Condition:	Blue Ice
Unit(s):	1 mg, 100 ug, 20 ug

Overview

Description

Description: Functions in nuclear protein import, either in association with an adapter protein, like an importin-alpha subunit, which binds to nuclear localization signals (NLS) in cargo substrates, or by acting as autonomous nuclear transport receptor. Acting autonomously, serves itself as NLS receptor. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. Mediates autonomously the nuclear import of ribosomal proteins RPL23A, RPS7 and RPL5. Binds to a beta-like import receptor binding (BIB) domain of RPL23A. In association with IPO7 mediates the nuclear import of H1 histone. In vitro, mediates nuclear import of H2A, H2B, H3 and H4 histones. In case of HIV-1 infection, binds and mediates the nuclear import of HIV-1 Rev. Imports SNAI1 and PRKCI into the nucleus .

Additional Text

Uniprot ID

P70168

Protein Tag

6xHIS Tag

Price

£1,581.00

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