Recombinant Mouse Telomerase reverse transcriptase (Tert), partial

Catalogue Number: CSB-EP023391MO-CSB

Manufacturer:	Cusabio Biotech
Shelf Life:	6 months
Molecular Weight:	54.1 kDa
Physical state:	Liquid or Lyophilized powder
Type:	DNA Polymerases
Alias:	Telomerase catalytic subunit
Host Cell:	E.coli
Shipping Condition:	Blue Ice
Unit(s):	1 mg, 100 ug, 20 ug
Host name:
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Immunogen:

Overview
Datasheets

Description

Description: Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. Active in progenitor and cancer cells. Inactive, or very low activity, in normal somatic cells. Catalytic component of the teleromerase holoenzyme complex whose main activity is the elongation of telomeres by acting as a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme. Catalyzes the RNA-dependent extension of 3'-chromosomal termini with the 6-nucleotide telomeric repeat unit, 5'-TTAGGG-3'. The catalytic cycle involves primer binding, primer extension and release of product once the template boundary has been reached or nascent product translocation followed by further extension. More active on substrates containing 2 or 3 telomeric repeats. Telomerase activity is regulated by a number of factors including telomerase complex-associated proteins, chaperones and polypeptide modifiers. Modulates Wnt signaling. Plays important roles in aging and antiapoptosis

Additional Text

Gene Name

TERT

Uniprot ID

O70372

Gene ID

21752

Protein Tag

6xHIS-SUMO Tag

Storage Note

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

CSB-EP023391MO MSDS

Price

£1,581.00

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