Recombinant Human Transmembrane protease serine 2(TMPRSS2),partial

Catalogue Number: CSB-EP023924HU-CSB

Manufacturer:Cusabio Biotech
Molecular Weight:46.9 kDa
Physical state:Liquid or Lyophilized powder
Type:Fusion Protein
Host Cell:E. Coli
Shipping Condition:Blue Ice
Unit(s): 1 mg, 100 ug, 20 ug


Description: Serine protease that proteolytically cleaves and activates the viral spike glycoproteins which facilitate virus-cell membrane fusions; spike proteins are synthesized and maintained in precursor intermediate folding states and proteolysis permits the refolding and energy release required to create stable virus-cell linkages and membrane coalescence. Facilitates human SARS coronavirus infection via two independent mechanisms, proteolytic cleavage of ACE2, which might promote viral uptake, and cleavage of coronavirus spike glycoprotein which activates the glycoprotein for cathepsin L-independent host cell entry. Proteolytically cleaves and activates the spike glycoproteins of human coronavirus 229E and human coronavirus EMC and the fusion glycoproteins F0 of Sendai virus, human metapneumovirus, human parainfluenza 1, 2, 3, 4a and 4b viruses . Essential for spread and pathogenesis of influenza A virus; involved in proteolytic cleavage and activation of hemagglutinin protein which is essential for viral infectivity.

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