Recombinant Measles virus Fusion glycoprotein F0 (F), partial

Catalogue Number: CSB-EP301654MCQ-CSB

Manufacturer:	Cusabio Biotech
Shelf Life:	6 months
Molecular Weight:	55.3 kda
Physical state:	Liquid or Lyophilized powder
Type:	Envelope Proteins
Host Cell:	E.coli
Shipping Condition:	Blue Ice
Unit(s):	1 mg, 100 ug, 20 ug
Host name:
Clone:
Isotype:
Immunogen:

Overview
Datasheets

Description

Description: Class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and plasma cell membrane fusion, the heptad repeat (HR) regions assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and plasma cell membranes. Directs fusion of viral and cellular membranes leading to delivery of the nucleocapsid into the cytoplasm. This fusion is pH independent and occurs directly at the outer cell membrane. The trimer of F1-F2 (F protein) probably interacts with H at the virion surface. Upon HN binding to its cellular receptor, the hydrophobic fusion peptide is unmasked and interacts with the cellular membrane, inducing the fusion between cell and virion membranes. Later in infection, F proteins expressed at the plasma membrane of infected cells could mediate fusion with adjacent cells to form syncytia, a cytopathic effect that could lead to tissue necrosis.

Additional Text

Protein Tag

6xHIS Tag

Gene ID

1489800

Gene Name

Uniprot ID

P69353

Storage Note

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

CSB-EP301654MCQ MSDS

Price

£1,581.00

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