Recombinant Lymphocytic choriomeningitis virus Nucleoprotein (N), partial
Catalogue Number: CSB-EP357108LKZ-CSB
| Manufacturer: | Cusabio Biotech |
| Shelf Life: | 6 months |
| Molecular Weight: | 44.8 kda |
| Physical state: | Liquid or Lyophilized powder |
| Type: | Other Enzymes |
| Alias: | (Nucleocapsid protein)(Protein N) |
| Host Cell: | E.coli |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg, 100 ug, 20 ug |
| Host name: | |
| Clone: | |
| Isotype: | |
| Immunogen: |
Description
Description: Encapsidates the genome, protecting it from nucleases. The encapsidated genomic RNA is termed the nucleocapsid (NC). Serves as template for viral transcription and replication. The increased presence of protein N in host cell does not seem to trigger the switch from transcription to replication as observed in other negative strain RNA viruses. Through the interaction with host IKBKE, strongly inhibits the phosphorylation and nuclear translocation of host IRF3, a protein involved in interferon activation pathway, leading to the inhibition of interferon-beta and IRF3-dependent promoters activation. Encodes also a functional 3'-5' exoribonuclease that degrades preferentially dsRNA substrates and thereby participates in the suppression of interferon induction.
Additional Text
Protein Tag
10xHIS Tag, Myc Tag
Storage Note
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
Uniprot ID
P07400
CSB-EP357108LKZ MSDS
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