Recombinant Human CD40 ligand (CD40LG), partial (Active)

Catalogue Number: CSB-MP004937HU3-CSB

Manufacturer:	Cusabio Biotech
Shelf Life:	6 months
Molecular Weight:	44.5 kda
Physical state:	Lyophilized
Type:	Cytokines
Alias:	(CD40-L)(T-cell antigen Gp39)(NF-related activation protein)(TRAP)(Tumor necrosis factor ligand superfamily member 5)(CD154)(sCD40L)
Host Cell:	Mammalian Cells
Shipping Condition:	Blue Ice
Unit(s):	100 ug, 20 ug, 1 mg
Host name:
Clone:
Isotype:
Immunogen:

Overview
Datasheets

Description

Description: Cytokine that acts as a ligand to CD40/TNFRSF5 (PubMed:1280226, PubMed:31331973). Costimulates T-cell proliferation and cytokine production (PubMed:8617933). Its cross-linking on T-cells generates a costimulatory signal which enhances the production of IL4 and IL10 in conjunction with the TCR/CD3 ligation and CD28 costimulation (PubMed:8617933). Induces the activation of NF-kappa-B (PubMed:15067037, PubMed:31331973). Induces the activation of kinases MAPK8 and PAK2 in T-cells (PubMed:15067037). Induces tyrosine phosphorylation of isoform 3 of CD28 (PubMed:15067037). Mediates B-cell proliferation in the absence of co-stimulus as well as IgE production in the presence of IL4 (By similarity). Involved in immunoglobulin class switching

Additional Text

Uniprot ID

P29965

Gene Name

CD40LG

Gene ID

959

Protein Tag

hFc-FLAG™ Tag

Storage Note

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

CSB-MP004937HU3 MSDS

Price

£274.00

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