Recombinant Human Ribonuclease T2 (RNASET2)
Catalogue Number: CSB-MP019810HU-CSB
| Manufacturer: | Cusabio Biotech |
| Shelf Life: | 6 months |
| Molecular Weight: | 56.1 kda |
| Physical state: | Liquid or Lyophilized powder |
| Type: | Ribonucleases (RNase) |
| Alias: | Ribonuclease 6 |
| Host Cell: | Mammalian Cells |
| Shipping Condition: | Blue Ice |
| Unit(s): | 1 mg, 100 ug, 20 ug |
| Host name: | |
| Clone: | |
| Isotype: | |
| Immunogen: |
Description
Description: Ribonuclease that plays an essential role in innate immune response by recognizing and degrading RNAs from microbial pathogens that are subsequently sensed by TLR8 (PubMed:31778653). Cleaves preferentially single-stranded RNA molecules between purine and uridine residues, which critically contributes to the supply of catabolic uridine and the generation of purine-2',3'-cyclophosphate-terminated oligoribonucleotides (PubMed:31778653). In turn, RNase T2 degradation products promote the RNA-dependent activation of TLR8 (PubMed:31778653). Plays also a key role in degradation of mitochondrial RNA and processing of non-coding RNA imported from the cytosol into mitochondria (PubMed:28730546, PubMed:30184494). Participates as well in degradation of mitochondrion-associated cytosolic rRNAs.
Additional Text
Gene ID
8635
Uniprot ID
O00584
Gene Name
RNASET2
Protein Tag
hFC Tag
Storage Note
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
CSB-MP019810HU MSDS
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