Recombinant Human Tumor necrosis factor ligand superfamily member 11 (TNFSF11), partial

Catalogue Number: CSB-MP023986HU(F2)-CSB

Manufacturer:	Cusabio Biotech
Shelf Life:	6 months
Molecular Weight:	22.7 kDa
Physical state:	Liquid or Lyophilized powder
Type:	Cytokines
Alias:	Osteoclast differentiation factor;ODF;Osteoprotegerin ligand;OPGL;Receptor activator of nuclear factor kappa-B ligand;RANKL;TNF-related activation-induced cytokine;TRANCE;CD254
Host Cell:	Mammalian Cells
Shipping Condition:	Blue Ice
Unit(s):	1 mg, 100 ug, 20 ug
Host name:
Clone:
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Immunogen:

Overview
Datasheets

Description

Description: Cytokine that binds to TNFRSF11B/OPG and to TNFRSF11A/RANK. Osteoclast differentiation and activation factor. Augments the ability of dendritic cells to stimulate naive T-cell proliferation. May be an important regulator of interactions between T-cells and dendritic cells and may play a role in the regulation of the T-cell-dependent immune response. May also play an important role in enhanced bone-resorption in humoral hypercalcemia of malignancy (PubMed:22664871). Induces osteoclastogenesis by activating multiple signaling pathways in osteoclast precursor cells, chief among which is induction of long lasting oscillations in the intracellular concentration of Ca (2+) resulting in the activation of NFATC1, which translocates to the nucleus and induces osteoclast-specific gene transcription to allow differentiation of osteoclasts. During osteoclast differentiation, in a TMEM64 and ATP2A2-dependent manner induces activation of CREB1 and mitochondrial ROS generation necessary for proper osteoclast generation.

Additional Text

Gene ID

8600

Gene Name

TNFSF11

Uniprot ID

O14788

Protein Tag

6xHIS Tag

Storage Note

The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.

CSB-MP023986HU(F2) MSDS

Price

£2,987.00

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