Recombinant Human Tyrosine-protein kinase Mer (MERTK), partial (Active)
Catalogue Number: CSB-MP621519HU-CSB
CSB-MP621519HU Image
CSB-MP621519HU Image
CSB-MP621519HU Image
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CSB-MP621519HU Image
Measured by its binding ability in a functional ELISA. Immobilized MERTK at 2 µg/mL can bind anti-MERTK antibody (CSB-RA621519A1HU) , the EC50 is 32.95-48.25 ng/mL.
| Manufacturer: | Cusabio Biotech |
| Shelf Life: | 6 months |
| Molecular Weight: | 55.4 kda |
| Physical state: | Lyophilized |
| Type: | Protein Kinases |
| Alias: | (Proto-oncogene c-Mer) (Receptor tyrosine kinase MerTK) |
| Host Cell: | Mammalian Cells |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 20 ug, 1 mg |
| Host name: | |
| Clone: | |
| Isotype: | |
| Immunogen: |
Description
Description: Receptor tyrosine kinase that transduces signals from the extracellular matrix into the cytoplasm by binding to several ligands including LGALS3, TUB, TULP1 or GAS6. Regulates many physiological processes including cell survival, migration, differentiation, and phagocytosis of apoptotic cells (efferocytosis). Ligand binding at the cell surface induces autophosphorylation of MERTK on its intracellular domain that provides docking sites for downstream signaling molecules. Following activation by ligand, interacts with GRB2 or PLCG2 and induces phosphorylation of MAPK1, MAPK2, FAK/PTK2 or RAC1. MERTK signaling plays a role in various processes such as macrophage clearance of apoptotic cells, platelet aggregation, cytoskeleton reorganization and engulfment. Functions in the retinal pigment epithelium (RPE) as a regulator of rod outer segments fragments phagocytosis. Plays also an important role in inhibition of Toll-like receptors (TLRs)-mediated innate immune response by activating STAT1, which selectively induces production of suppressors of cytokine signaling SOCS1 and SOCS3.
Additional Text
Uniprot ID
Q12866
Gene Name
MERTK
Gene ID
10461
Protein Tag
10xHIS Tag
Storage Note
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
CSB-MP621519HU MSDS
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