Recombinant Human E3 ubiquitin-protein ligase ZNRF3 (ZNRF3), partial (Active)
Catalogue Number: CSB-MP890933HU-CSB
CSB-MP890933HU Image
CSB-MP890933HU Image
CSB-MP890933HU Image
(Tris-Glycine gel) Discontinuous SDS-PAGE (reduced) with 5% enrichment gel and 15% separation gel.
CSB-MP890933HU Image
Measured by its binding ability in a functional ELISA. Immobilized Human ZNRF3 at 5 µg/mL can bind Human RSPO2 (CSB-MP751021HU1(M)), the EC50 is 5.091-6.991 ng/mL.
| Manufacturer: | Cusabio Biotech |
| Shelf Life: | 6 months |
| Molecular Weight: | 20.4 kda |
| Physical state: | Lyophilized |
| Type: | Transferases |
| Alias: | (RING finger protein 203)(RING-type E3 ubiquitin transferase ZNRF3)(Zinc/RING finger protein 3) |
| Host Cell: | Mammalian Cells |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 20 ug, 1 mg |
| Host name: | |
| Clone: | |
| Isotype: | |
| Immunogen: |
Description
Description: E3 ubiquitin-protein ligase that acts as a negative regulator of the Wnt signaling pathway by mediating the ubiquitination and subsequent degradation of Wnt receptor complex components Frizzled and LRP6. Acts on both canonical and non-canonical Wnt signaling pathway. Acts as a tumor suppressor in the intestinal stem cell zone by inhibiting the Wnt signaling pathway, thereby resticting the size of the intestinal stem cell zone . Along with RSPO2 and RNF43, constitutes a master switch that governs limb specification.
Additional Text
Uniprot ID
Q9ULT6
Gene ID
84133
Gene Name
ZNRF3
Protein Tag
6xHIS Tag
Storage Note
The shelf life is related to many factors, storage state, buffer ingredients, storage temperature and the stability of the protein itself. Generally, the shelf life of liquid form is 6 months at -20°C/-80°C. The shelf life of lyophilized form is 12 months at -20°C/-80°C.
CSB-MP890933HU MSDS
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