ANPEP Antibody

Catalogue Number: CSB-PA001827LA01HU-CSB

Manufacturer:Cusabio Biotech
Preservative:0.03% ProClin™ 300
Physical state:Liquid
Type:Polyclonal Primary Antibody - Unconjugated
Alias:Aminopeptidase N (AP-N) (hAPN) (EC (Alanyl aminopeptidase) (Aminopeptidase M) (AP-M) (Microsomal aminopeptidase) (Myeloid plasma membrane glycoprotein CD13) (gp150) (CD antigen CD13), ANPEP, APN CD13 PEPN
Shipping Condition:Blue Ice
Unit(s): 100 ug, 50 ug
Host name: Rabbit
Isotype: IgG
Immunogen: Recombinant Human Aminopeptidase N protein (34-219AA)
Application: ELISA, IF, WB, IHC


Description: Broad specificity aminopeptidase. Plays a role in the final digestion of peptides generated from hydrolysis of proteins by gastric and pancreatic proteases. May play a critical role in the pathogenesis of cholesterol gallstone disease. May be involved in the metabolism of regulatory peptides of diverse cell types, responsible for the processing of peptide hormones, such as angiotensin III and IV, neuropeptides, and chemokines. Found to cleave antigen peptides bound to major histocompatibility complex class II molecules of presenting cells and to degrade neurotransmitters at synaptic junctions. Is also implicated as a regulator of IL-8 bioavailability in the endometrium, and therefore may contribute to the regulation of angiogenesis. Is used as a marker for acute myeloid leukemia and plays a role in tumor invasion. In case of human coronavirus 229E (HCoV-229E) infection, serves as receptor for HCoV-229E spike glycoprotein. Mediates as well human cytomegalovirus (HCMV) infection.

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