IFIT3 Antibody
Catalogue Number: CSB-PA011022HA01HU-CSB
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Western Blot Positive WB detected in: A549 whole cell lysate All lanes: IFIT3 antibody at 3.3µg/ml Secondary Goat polyclonal to rabbit IgG at 1/50000 dilution Predicted band size: 56 kDa Observed band size: 56 kDa
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Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA011022HA01HU at dilution of 1:100
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Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA011022HA01HU at dilution of 1:100
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Immunofluorescent analysis of HepG2 cells using CSB-PA011022HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Immunoprecipitating IFIT3 in HepG2 whole cell lysate Lane 1: Rabbit control IgG (1µg) instead of CSB-PA011022HA01HU in HepG2 whole cell lysate. For western blotting, a HRP-conjugated Protein G antibody was used as the secondary antibody (1/2000) Lane 2: CSB-PA011022HA01HU (6µg) + HepG2 whole cell lysate (500µg) Lane 3: HepG2 whole cell lysate (10µg)
| Manufacturer: | Cusabio Biotech |
| Preservative: | 0.03% ProClin™ 300 |
| Ph: | 7.4 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 50 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant Human Interferon-induced protein with tetratricopeptide repeats 3 protein (1-490AA) |
| Application: | ELISA, IF, IP, WB, IHC |
Description
Description: IFN-induced antiviral protein which acts as an inhibitor of cellular as well as viral processes, cell migration, proliferation, signaling, and viral replication. Enhances MAVS-mediated host antiviral responses by serving as an adapter bridging TBK1 to MAVS which leads to the activation of TBK1 and phosphorylation of IRF3 and phosphorylated IRF3 translocates into nucleus to promote antiviral gene transcription. Exihibits an antiproliferative activity via the up-regulation of cell cycle negative regulators CDKN1A/p21 and CDKN1B/p27. Normally, CDKN1B/p27 turnover is regulated by COPS5, which binds CDKN1B/p27 in the nucleus and exports it to the cytoplasm for ubiquitin-dependent degradation. IFIT3 sequesters COPS5 in the cytoplasm, thereby increasing nuclear CDKN1B/p27 protein levels. Upregulates CDKN1A/p21 by downregulating MYC, a repressor of CDKN1A/p21. Can negatively regulate the apoptotic effects of IFIT2.
Additional Text
Gene Name
IFIT3
Uniprot ID
O14879
Purification
Protein G purified
Gene ID
3437
Storage Note
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Antibody Clonality
Polyclonal
Specificity
CIG 49 antibody; CIG49 antibody; GARG 49 antibody; IFI-60K antibody; IFI60 antibody; IFI60K antibody; IFIT-3 antibody; IFIT-4 antibody; Ifit3 antibody; IFIT3_HUMAN antibody; IFIT4 antibody; Interferon induced 60 kDa protein antibody; Interferon induced protein 60 antibody; Interferon induced protein with tetratricopeptide repeats 3 antibody; Interferon-induced 60 kDa protein antibody; Interferon-induced protein with tetratricopeptide repeats 3 antibody; Interferon-induced protein with tetratricopeptide repeats 4 antibody; IRG2 antibody; ISG-60 antibody; ISG60 antibody; P60 antibody; Retinoic acid induced gene G protein antibody; Retinoic acid-induced gene G protein antibody; RIG G antibody; RIG-G antibody; RIGG antibody; RP11-149I23.4 antibody
CSB-PA011022HA01HU Datasheet
SUPPORT
outstanding technical support
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DELIVERY
we offer free delivery to UK universities and non profit organisations