SMARCA2 Antibody
Catalogue Number: CSB-PA021799LA01HU-CSB
CSB-PA021799LA01HU Image
CSB-PA021799LA01HU Image
CSB-PA021799LA01HU Image
CSB-PA021799LA01HU Image
Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA021799LA01HU at dilution of 1:100
CSB-PA021799LA01HU Image
Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA021799LA01HU at dilution of 1:100
CSB-PA021799LA01HU Image
Chromatin Immunoprecipitation Hela (1.1*106) were cross-linked with formaldehyde, sonicated, and immunoprecipitated with 4µg anti-SMARCA2 or a control normal rabbit IgG. The resulting ChIP DNA was quantified using real-time PCR with primers (CSB-PP021799HU) against the ESR1 pS2 promoter.
| Manufacturer: | Cusabio Biotech |
| Preservative: | 0.03% ProClin™ 300 |
| Ph: | 7.4 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ug, 50 ug |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant Human Probable global transcription activator SNF2L2 protein (700-1216AA) |
| Application: | ELISA, ChIP, IHC |
Description
Description: Transcriptional coactivator cooperating with nuclear hormone receptors to potentiate transcriptional activation. Also involved in vitamin D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the CYP27B1 gene. Belongs to the neural progenitors-specific chromatin remodeling complex (npBAF complex) and the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth.
Additional Text
Gene ID
6595
Gene Name
SMARCA2
Uniprot ID
P51531
Purification
Protein G purified
Storage Note
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Antibody Clonality
Polyclonal
Specificity
ATP dependent helicase SMARCA2 antibody; ATP-dependent helicase SMARCA2 antibody; BAF190 antibody; BAF190B antibody; BRG1-associated factor 190B antibody; BRM antibody; FLJ36757 antibody; Global transcription activator homologous sequence antibody; hBRM antibody; hSNF2a antibody; MGC74511 antibody; Possible global transcription activator SNF2L2 antibody; Probable global transcription activator SNF2L2 antibody; Protein brahma homolog antibody; SMARCA2 antibody; SMCA2_HUMAN antibody; SNF2 alpha antibody; SNF2 like 2 antibody; SNF2-alpha antibody; SNF2/SWI2 like protein 2 antibody; SNF2L2 antibody; SNF2LA antibody; Sth1p antibody; Sucrose nonfermenting 2 like protein 2 antibody; SWI/SNF related matrix associated actin dependent regulator of chromatin subfamily A member 2 antibody; SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 2 antibody
CSB-PA021799LA01HU Datasheet
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DELIVERY
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