TAP1 Antibody
Catalogue Number: CSB-PA023120ESR1HU-CSB
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CSB-PA023120ESR1HU Image
CSB-PA023120ESR1HU Image
CSB-PA023120ESR1HU Image
CSB-PA023120ESR1HU Image
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Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA023120ESR1HU at dilution of 1:100
CSB-PA023120ESR1HU Image
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA023120ESR1HU at dilution of 1:100
CSB-PA023120ESR1HU Image
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA023120ESR1HU at dilution of 1:100
CSB-PA023120ESR1HU Image
Immunohistochemistry of paraffin-embedded human cervical cancer using CSB-PA023120ESR1HU at dilution of 1:100
CSB-PA023120ESR1HU Image
Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA023120ESR1HU at dilution of 1:100
CSB-PA023120ESR1HU Image
Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA023120ESR1HU at dilution of 1:100
| Manufacturer: | Cusabio Biotech |
| Preservative: | 0.02% Sodium azide |
| Ph: | 7.3 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 50 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Recombinant Human Antigen peptide transporter 1 protein (524-808AA) |
| Application: | ELISA, IHC |
Description
Description: Involved in the transport of antigens from the cytoplasm to the endoplasmic reticulum for association with MHC class I molecules. Also acts as a molecular scaffold for the final stage of MHC class I folding, namely the binding of peptide. Nascent MHC class I molecules associate with TAP via tapasin. Inhibited by the covalent attachment of herpes simplex virus ICP47 protein, which blocks the peptide-binding site of TAP. Inhibited by human cytomegalovirus US6 glycoprotein, which binds to the lumenal side of the TAP complex and inhibits peptide translocation by specifically blocking ATP-binding to TAP1 and prevents the conformational rearrangement of TAP induced by peptide binding. Inhibited by human adenovirus E3-19K glycoprotein, which binds the TAP complex and acts as a tapasin inhibitor, preventing MHC class I/TAP association. Expression of TAP1 is down-regulated by human Epstein-Barr virus vIL-10 protein, thereby affecting the transport of peptides into the endoplasmic reticulum and subsequent peptide loading by MHC class I molecules.
Additional Text
Gene Name
TAP1
Uniprot ID
Q03518
Purification
Affinity Purified
Gene ID
6890
Antibody Clonality
Polyclonal
Specificity
ABC 17 antibody; ABC transporter MHC 1 antibody; ABC17 antibody; ABCB 2 antibody; ABCB2 antibody; Antigen peptide transporter 1 antibody; APT 1 antibody; APT1 antibody; ATP binding cassette sub family B (MDR/TAP) member 2 antibody; ATP binding cassette sub family B member 2 antibody; ATP binding cassette transporter antibody; ATP-binding cassette sub-family B member 2 antibody; D6S114E antibody; FLJ26666 antibody; FLJ41500 antibody; Peptide supply factor 1 antibody; Peptide transporter involved in antigen processing 1 antibody; Peptide transporter PSF 1 antibody; Peptide transporter PSF1 antibody; Peptide transporter TAP 1 antibody; Peptide transporter TAP1 antibody; PSF 1 antibody; PSF-1 antibody; PSF1 antibody; Really interesting new gene 4 protein antibody; RING 4 antibody; RING4 antibody; TAP 1 antibody; TAP1 antibody; TAP1*0102N antibody; TAP1_HUMAN antibody; TAP1N antibody; Transporter 1 ATP binding cassette sub family B (MDR/TAP) antibody; Transporter 1 ATP binding cassette sub family B antibody; Transporter associated with antigen processing antibody; Transporter ATP binding cassette major histocompatibility complex 1 antibody; Y3 antibody
CSB-PA023120ESR1HU Datasheet
SUPPORT
outstanding technical support
PRODUCT
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DELIVERY
we offer free delivery to UK universities and non profit organisations