HLA-E Antibody, HRP conjugated

Catalogue Number: CSB-PA320269LB01HU-CSB

Manufacturer:Cusabio Biotech
Preservative:0.03% ProClin™ 300
Ph:7.4
Physical state:Liquid
Type:Polyclonal Primary Antibody - Conjugated
Alias:HLA-E antibody; HLA-6.2 antibody; HLAEHLA class I histocompatibility antigen antibody; alpha chain E antibody; MHC class I antigen E) [Cleaved into: Soluble HLA class I histocompatibility antigen antibody; alpha chain E antibody; sHLA-E)] antibody
Shipping Condition:Blue Ice
Unit(s): 100 ug, 50 ug
Host name: Rabbit
Clone:
Isotype: IgG
Immunogen: Recombinant Human HLA class I histocompatibility antigen, alpha chain E protein (33-261AA)
Application: ELISA

Description

Description: Non-classical major histocompatibility class Ib molecule involved in immune self-nonself discrimination. In complex with B2M/beta-2-microglobulin binds nonamer self-peptides derived from the signal sequence of classical MHC class Ia molecules (VL9 peptides) (PubMed:9754572, PubMed:18083576, PubMed:18339401). Peptide-bound HLA-E-B2M heterotrimeric complex primarily functions as a ligand for natural killer (NK) cell inhibitory receptor KLRD1-KLRC1, enabling NK cells to monitor the expression of other MHC class I molecules in healthy cells and to tolerate self (PubMed:9754572, PubMed:9486650, PubMed:17179229, PubMed:18083576). Upon cellular stress, preferentially binds signal sequence-derived peptides from stress-induced chaperones and is no longer recognized by NK cell inhibitory receptor KLRD1-KLRC1, resulting in impaired protection from NK cells (PubMed:12461076). Binds signal sequence-derived peptides from non-classical MHC class Ib HLA-G molecules and acts as a ligand for NK cell activating receptor KLRD1-KLRC2, likely playing a role in the generation and effector functions of adaptive NK cells and in maternal-fetal tolerance during pregnancy (PubMed:9754572, PubMed:30134159). Besides self-peptides, can also bind and present pathogen-derived peptides conformationally similar to VL9 peptides to alpha-beta T cell receptor (TCR) on unconventional CD8+ cytotoxic T cells, ultimately triggering antimicrobial immune response (PubMed:16474394, PubMed:30087334).

Additional Text

Gene ID

3133

Gene Name

HLA-E

Uniprot ID

P13747

Purification

Affinity Purified

Antibody Clonality

Polyclonal