Catalogue Number: CSB-PA336163EA01HIY-CSB
|Preservative:||0.03% ProClin™ 300|
|Type:||Polyclonal Primary Antibody - Unconjugated|
|Alias:||Spike glycoprotein (S glycoprotein) (E2) (Peplomer protein) [Cleaved into: Spike protein S1 (90B); Spike protein S2 (90A)], S|
|Shipping Condition:||Blue Ice|
|Unit(s):||100 ug, 50 ug|
|Immunogen:||Recombinant Human coronavirus OC43 Spike glycoprotein protein (15-344AA)|
Description: S1 attaches the virion to the cell membrane by interacting with sialic acid-containing cell receptors, initiating the infection. S2 is a class I viral fusion protein. Under the current model, the protein has at least 3 conformational states: pre-fusion native state, pre-hairpin intermediate state, and post-fusion hairpin state. During viral and target cell membrane fusion, the coiled coil regions (heptad repeats) assume a trimer-of-hairpins structure, positioning the fusion peptide in close proximity to the C-terminal region of the ectodomain. The formation of this structure appears to drive apposition and subsequent fusion of viral and target cell membranes.