ERN2 Antibody
Catalogue Number: CSB-PA436972-CSB
CSB-PA436972 image
CSB-PA436972 image
CSB-PA436972 Image
CSB-PA436972 Image
CSB-PA436972 image
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA585877(ERN2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
CSB-PA436972 image
The image on the left is immunohistochemistry of paraffin-embedded Human gastric cancer tissue using CSB-PA585877(ERN2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: ×200)
CSB-PA436972 Image
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using CSB-PA436972(ERN2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200)
CSB-PA436972 Image
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using CSB-PA436972(ERN2 Antibody) at dilution 1/40, on the right is treated with synthetic peptide. (Original magnification: x200)
| Manufacturer: | Cusabio Biotech |
| Preservative: | 0.05% Sodium azide |
| Ph: | 7.4 |
| Physical state: | Liquid |
| Type: | Polyclonal Primary Antibody - Unconjugated |
| Shipping Condition: | Blue Ice |
| Unit(s): | 100 ul, 50 ul |
| Host name: | Rabbit |
| Clone: | |
| Isotype: | IgG |
| Immunogen: | Synthetic peptide of Human ERN2 |
| Application: | ELISA, IHC |
Description
Description: The accumulation of unfolded proteins within the endoplasmic recticulum (ER) of yeast and mammalian cells activates the unfolded protein response (UPR) pathway and leads to the transcription of ER-specific genes involved in protein folding. The activation of the UPR requires the ER transmembrane kinase IRE1p (for inositol-requiring and ER-to-nucleus signaling protein). IRE1α and IRE1β are two mammalian homologs of the yeast IRE1p. These related proteins localize to the ER lumen and contain both a short transmembrane domain that spans the ER membrane and a cytosolic Ser/Thr kinase domain. IRE1 activation involves the oligomerization and trans-phosphorylation of the cytosolic portion of the proteins, which then potentiates its intrinsic kinase activity and, in turn, stimulates transcription of UPR-targeted genes.
Additional Text
Gene ID
10595
Gene Name
ERN2
Uniprot ID
Q76MJ5
Purification
Affinity Purified
Storage Note
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Antibody Clonality
Polyclonal
Specificity
ERN2 antibody; IRE2Serine/threonine-protein kinase/endoribonuclease IRE2 antibody; Endoplasmic reticulum-to-nucleus signaling 2 antibody; Inositol-requiring protein 2 antibody; hIRE2p antibody; Ire1-beta antibody; IRE1b) [Includes: Serine/threonine-protein kinase antibody; EC 2.7.11.1); Endoribonuclease antibody; EC 3.1.26.-)] antibody
CSB-PA436972 Datasheet
SUPPORT
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PRODUCT
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DELIVERY
we offer free delivery to UK universities and non profit organisations